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What are some medications I can take for insomnia?

Dr. Eric P. Eck, DO

March 29, 2023

There are several medications that can be used to treat sleep problems, but it's important to note that they should only be used under the guidance of a healthcare professional. Here are some examples:

  1. Sedative-hypnotics: These medications are typically used for short-term treatment of sleep problems, such as insomnia. Benzodiazepines work by enhancing the activity of GABA, a neurotransmitter that slows down brain activity, while non-benzodiazepines work by targeting specific receptors in the brain. They can be effective in helping people fall asleep, but can also have side effects such as dizziness, confusion, and impaired coordination. Additionally, they can be habit-forming, which can lead to dependence and withdrawal symptoms when stopped abruptly. As a result, they are generally recommended only for short-term use.
  2. Antidepressants: While antidepressants are primarily used to treat depression, some of them can also be effective in treating sleep problems. Trazodone, for example, is sometimes used off-label to treat insomnia because it can cause drowsiness. However, it can also have side effects such as dry mouth, dizziness, and blurred vision. Doxepin is another antidepressant that is sometimes used to treat insomnia. It works by blocking histamine receptors, which can cause drowsiness. However, it can also cause side effects such as dry mouth, dizziness, and constipation.
  3. Melatonin: Melatonin is a hormone that is naturally produced by the body to help regulate sleep-wake cycles. Melatonin supplements are available over-the-counter and are often used to treat insomnia, particularly for people who have trouble falling asleep. While melatonin is generally considered safe, it can cause side effects such as headaches, dizziness, and nausea. It can also interact with certain medications, so it's important to talk to a healthcare professional before taking melatonin.
  4. Antihistamines: Over-the-counter antihistamines, such as diphenhydramine (Benadryl), are sometimes used to help with sleep problems. They work by blocking histamine receptors, which can cause drowsiness. However, they can also cause side effects such as dry mouth, blurred vision, and constipation. Additionally, they can be habit-forming and may cause daytime drowsiness.

It's important to note that medication should be used as a last resort for treating sleep problems, and only under the guidance of a healthcare professional. Non-pharmacological approaches, such as improving sleep hygiene and cognitive-behavioral therapy, are generally recommended as the first line of treatment. Additionally, all medications can have potential side effects and risks, and should only be used as directed by a healthcare professional.


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